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Updated: March 24, 2016Applies To: System Center 2012 R2 Endpoint Protection, System Center 2012 Configuration Manager, System Center 2012 Configuration Manager SP1, System Center 2012 Configuration Manager SP2, System Center 2012 R2 Configuration Manager, System Center 2012 Endpoint Protection SP1, System Center 2012 Endpoint Protection, System Center 2012 R2 Configuration Manager SP1If you manage endpoint protection for Windows 10 computers, then you must configure System Center 2012 Configuration Manager to update and distribute malware definitions for Windows Defender.